![]() ![]() The STARS trial was a phase III randomized controlled trial that compared the effects of adjuvant radiation therapy (RT), CCRT, and sequential chemoradiation therapy (SCRT) in the International Federation of Gynaecology and Obstetrics (FIGO) stage IB–IIB patients with one or more risk factors for recurrence after radical hysterectomy. In this review, we compared salpingectomy with delayed oophorectomy and salpingo-oophorectomy in terms of quality of life in BRCA 1 and 2 pathogenic variant carriers. The survival differences between the intensive and minimalist follow-up protocols were also described. For uterine corpus cancer, dostarlimab (anti-programmed cell death protein 1 antibody) alone, or a tyrosine kinase inhibitor in combination with pembrolizumab for advanced, metastatic, or recurrent endometrial cancer were reviewed. The rechallenge of poly (ADP-ribose) polymerase inhibitor maintenance in heavily pretreated ovarian cancer were also addressed. Ovarian cancer research included studies of secondary cytoreductive surgery in platinum-sensitive recurrent ovarian cancer, and various trials of immune checkpoint inhibitors with or without vascular endothelial growth factor inhibitors and conventional chemotherapy. A review of cervical cancer included adjuvant treatments such as radiation and chemoradiation (concurrent or sequential) after radical hysterectomy in early cervical cancer, and immune checkpoint inhibitors in advanced, recurrent, and metastatic disease. In the 2021 series, we not only summarized the major clinical research advances in gynecologic oncology but also added discussions to every part, based on communications at the conference. Jeong-Yeol Park, 1, * Jung-Yun Lee, 2, * Yoo-Young Lee, 3, * Seung-Hyuk Shim, 4 Dong Hoon Suh, 5ġDepartment of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ĢDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.ģDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ĤDepartment of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.ĥDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ĦDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. Major clinical research advances in gynecologic cancer in 2021 Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology ![]()
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